Hitomi Shimizu is a composer of live action films, television programs, animated shorts and videogames. Her score for the 2001 comedy Waterboys, composed with Gakuji Matsuda, won the Japan Academy Prize for best film score.

She also contributed music to the short animation films by Kōji Yamamura, such as Mt.Head which won the top prize at the 27th Annecy International Animation Film Festival, and was nominated for the Academy Award for Best Animated Short Film. That film also won the Best Soundtrack Creation Award at the Clermont-Ferrand International Short Film Festival.

Hitomi is part of a musical duo with violinist Hiromi Nishida called Syzygys.

Syzygys' albums are reissued by producer, John Zorn on his Tzadik label. 
Syzygys wrote original score for  Netflix film "Dick Johnson Is Dead" directed by Kirsten Johnson.

Hitomi also specializes in horror music such as

Playstation "SIREN" series. The theme song"Hoshin Goeika" is known as " the scariest song" in the horror game world.

Microtonal music is her life work. With her selfmade microtonal reed organ ( Harry Partch's 43tone scale)and custom made Tonal Plexus keyboard, she  has  solo performances in Japan.